Main Hoon Na is all about the dual mission of love relation -which he has to complete with love and gun. Major Ram Prasad Sharma (SRK) is on 'Mission Milaap' to regain peace between India-Pakistan relationships. Raghavan (Suniel Shetty) casts his dark shadow on General Amerjeet Bakshi's daughter, Sanjana (Amrita Rao). Major Sharma then join school to protect her.